NAD+

Safety Considerations

NAD+ is well tolerated when dosed appropriately. High-dose IV or IM therapy may cause temporary flushing, chest tightness, nausea, or warmth due to its rapid systemic activation—especially if infused too quickly. Slower administration or titration over time minimizes these effects. For injectable protocols, NAD+ is often cycled or micro-dosed daily to avoid cofactor saturation and promote consistent mitochondrial signaling. It is non-toxic, non-suppressive, and can be used long-term as a foundational tool in anti aging and metabolic programs.

Molecule / Formula

C21H27N7O14P2

NAD+1000mg/5mL DOSING

  • 5 units low dose

  • 7.5 units moderate dose

  • 10-12.5 units typical dose

    Start low, acclimate, titrate up based on how you feel

What Is the NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a vital coenzyme found in every living cell, responsible for powering over 500 enzymatic reactions tied to energy production, DNA repair, and cellular longevity. It exists in two forms: NAD+ (oxidized) and NADH (reduced), functioning as a molecular battery carrying electrons from one reaction to another during metabolic processes. As we age, NAD+ levels decline sharply, leading to decreased mitochondrial function, impaired cellular repair, and increased oxidative stress. Replenishing NAD+ has become one of the most cutting- edge anti-aging and metabolic optimization strategies available in modern regenerative medicine.

How It Works

NAD+ serves as a cofactor in redox reactions, primarily within the Krebs cycle and electron transport chain, where it plays a central role in ATP production the body’s main energy currency. Beyond its metabolic duties, NAD+ is a substrate for sirtuins and PARPs enzymes critical for DNA repair, gene expression, and cell survival. Sirtuins, often called "longevity genes," depend entirely on NAD+ to function. As NAD+ levels drop, these protective systems downregulate, accelerating cellular aging and metabolic dysfunction. By restoring NAD+, we reactivate these longevity pathways, enhancing mitochondrial efficiency, reducing inflammation, and boosting cellular resilience. It also improves neurotransmitter function by supporting dopamine and serotonin synthesis, making it a powerful cognitive enhancer and mood stabilizer..

Benefits

NAD+ supplementation has been shown to provide broad-spectrum cellular and neurological benefits:

  • Increased energy production at the mitochondrial level

  • Enhanced mental clarity, memory, and cognitive performance

  • Improved metabolic function and insulin sensitivity

  • Reductvion in inflammation and oxidative stress

  • Faster cellular repair and recovery

  • Support for addiction recovery and neurological detox

  • Improved skin health, elasticity, and collagen regeneration

  • Potential lifespan extension via sirtuin activation